We are dedicated to develop science and technologies for the detection, control and prevention of existing, emerging and re-emerging infectious diseases for population health.
Infectious viral diseases are one of the leading causes of human deaths worldwide. The COVID-19 pandemic has unequivocally demonstrated the need of new tools to anticipate viral presence and transmission before it spreads through communities. Wastewater surveillance has been efficient to indicate viral presence and penetration in the community, as demonstrated by early work from our group and peers.
We aims to develop early-warning systems to monitor the emergence and spread of viral diseases in the population. Leveraging molecular virology, genomic sequencing, and biostatistical approaches, we seek to:
1) develop longitudinal wastewater surveillance to monitor the transmission and dynamics of infectious viral agents in the community at spatial-temporal scales;
2) track the evolution of genomic variants emerging in the population;
3) integrate wastewater data with neighborhood demographic and health metadata to identify public health issues including health inequality and disparity.
Viral metagenomics and discovery
The world has seen 16 major viral disease outbreaks in the last two decades, including Dengue, SARS-CoV, H1N1, Ebola, MERS-CoV and SARS-CoV-2. Although we have the technology and social protocols to respond to viral epidemics, it is challenging to predict and prepare for future outbreaks. Pandemic preparedness is further impaired by our limited understanding of viral diversity in humans and other mammals. In this project, we aim to develop tools including metagenomic sequencing and analysis to uncover the human viral diversity, with the dream to create a global map of human virus.
Microbiome and Medicine
Microbiome plays important roles in human health and influences host responses to infectious diseases and medicine. As a dynamic system, gut microbiome changes with external diet and environmental variations as well as the internal interactions from the ~10^13 microbial residents in hundreds of species. Keeping our heads in Clouds to probe their biological and ecological roles in the gut, we are curious to explore those straightforward but challenging questions:
1) How to reduce the side effects of antibiotics on gut microbiota?
2) How does the medicine we take every day alter our microbiome?
3) Can we balance the microbiota for a health gut?
Get in touch with us at firstname.lastname@example.org